Atrial Fibrillation Genetics Update: Toward Clinical Implementation
نویسندگان
چکیده
منابع مشابه
Genetics of atrial fibrillation.
Recent studies of AF have identified mutations in a series of ion channels; however, these mutations appear to be relatively rare causes of AF. A genome-wide association study has identified novel variants on chromosome 4 associated with AF, although the mechanism of action for these variants remains unknown. Ultimately, a greater understanding of the genetics of AF should yield insights into n...
متن کاملMolecular genetics of atrial fibrillation.
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia. There is genetic predisposition for the development of AF. Recently, by linkage analysis, several loci have been mapped for monogenetic AF, including 11p15.5, 21q22, 17q, 7q35-36, 5p13, 6q14-16, and 10q22. Some of these loci encode for subunits of potassium channels (KCNQ1, KCNE2, KCNJ2, and KCNH2 genes), and the remainin...
متن کاملMapping Atrial Fibrillation: 2015 Update.
Atrial fibrillation requires a trigger that initiates the arrhythmia and substrate that favors perpetuation. Cardiac mapping is necessary to locate triggers and substrate so that an ablation strategy can be optimized. The most commonly used cardiac mapping approach is isochronal or activation mapping, which aims to create a spatial model of electrical wavefront propagation. Historically, activa...
متن کاملThe complex genetics of atrial fibrillation.
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, affecting 1% to 2% of the populations of North America and Europe and up to 9% of people 80 ears of age (1,2). Appropriate recognition and treatment an diminish the likelihood of its 2 most serious complicaions, stroke and heart failure (3). The great majority of AF s attributable to underlying structural heart disease, a...
متن کاملUpdate on the management of atrial fibrillation.
Atrial fibrillation (AF) is a common arrhythmia, with a prevalence that increases markedly with increasing age. Presence of AF has implications for management of future stroke risk. If the patient's pulse is irregular, an electrocardiogram should be ordered. Key management decisions are whether to adopt a rhythm control or a rate control strategy and whether to initiate anticoagulation. The pri...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Frontiers in Cardiovascular Medicine
سال: 2019
ISSN: 2297-055X
DOI: 10.3389/fcvm.2019.00127